Manganese-enhanced magnetic resonance imaging …
Manganese-enhanced magnetic resonance imaging (MEMRI) Alan P. Koretsky* and Afonso C. Silva Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA Received 3 October 2004; Revised 6 October 2004; Accepted 6 October 2004
Manganese-enhanced magnetic resonance imaging (MEMRI…
Divalent manganese ion (Mn2+) has been reported to be a useful contrast agent for functional MRI, through a technique named activity-induced manganese-dependent MRI (AIM). In AIM, signal enhancement is related to functional increases in calcium influx, and therefore AIM is, thus far, the only MRI me …
In Vivo Tracking of Transplanted Mononuclear Cells Using …
The hypothesis that MRI can provide in vivo detection and long-term observation of MNCs labeled with manganese contrast-agent was investigated in ischemic rat legs. Methods and Findings The Mn-labeled MNCs were evaluated using 7-tesla high-field magnetic resonance imaging (MRI).
Manganese-enhanced magnetic resonance imaging
Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T (1) relaxation time of tissue water protons that become exposed to paramagnetic manganese ions. In experimental animals, the technique combines the high spatial resolution achievable by …
Manganese-enhanced magnetic resonance imaging (MEMRI…
Manganese-enhanced MRI (MEMRI) is being increasingly used for MRI in animals due to the unique T1 contrast that is sensitive to a number of biological processes.
Cocaine-induced brain activation detected by dynamic …
Dynamic manganese-enhanced magnetic resonance imaging (MEMRI) detects neuronal activity based on the passage of Mn 2+ into active neurons. Because this mechanism is independent of any hemodynamic response, it is potentially ideal for pharmacological studies and was applied to investigate the acute CNS effects of …
In vivo, trans-synaptic tract-tracing utilizing manganese-enhanced
Manganese-enhanced MRI (MEMRI) utilizes a combination of these properties of Mn2+ to trace neuronal pathways in an MRI-detectable manner. The focus of this review will detail some of the current MEMRI tract-tracing methodologies in mice and non-human primates as well as biological applications of MEMRI tract-tracing.
Frontiers | Manganese-Enhanced Magnetic Resonance Imaging…
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system …
Manganese-Enhanced Magnetic Resonance Imaging: …
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the …
In vivo, trans-synaptic tract-tracing utilizing manganese-enhanced
Manganese-enhanced magnetic resonance imaging (MEMRI) ... study showed that Mn 2+ could aid in the visualization of reactive astrogliosis with manganeseenhanced magnetic resonance imaging (MEMRI ...
Applications of manganese-enhanced magnetic resonance imaging (MEMRI
The use of manganese-based MRI contrast materials, either manganese salts or chelates, has spanned the entire timeframe of cardiac MRI. However interest in Mn compounds for cardiac MRI has been sporadic because of concerns over cardiotoxicity associated with significant concentration of free Mn2+ an …
Manganese‐enhanced magnetic resonance imaging …
Three specific uses of MEMRI have been demonstrated: to visualize activity in the brain and the heart; to trace neuronal specific connections in the brain; and to …
Manganese-enhanced magnetic resonance imaging (MEMRI)
This special issue of NMR in Biomedicine on manganese-enhanced MRI (MEMRI) is aimed at providing the readers of this journal with an extensive review of some of the most prominent applications of MEMRI in biological systems. Written by several of the leaders in the field, the reviews and original research articles featured in this special …
Frontiers | In vivo evaluation of cellular activity in αCaMKII
These changes could be caused by disturbances in neuronal signal transduction; however, it is still unclear whether neuronal activity is reduced in these regions. In this study, we performed in vivo manganese-enhanced magnetic resonance imaging (MEMRI) to assess the regional cellular activity in the brains of αCaMKII HKO …
(PDF) In Vivo Tracking of Transplanted Mononuclear Cells …
In Vivo Tracking of Transplanted Mononuclear Cells Using Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) Kenichi Odaka1, Ichio Aoki1*, Junji Moriya2, Kaoru Tateno2, Hiroyuki Tadokoro3, Jeff Kershaw1, Tohru Minamino2, Toshiaki Irie1, Toshimitsu Fukumura1, Issei Komuro2, Tsuneo Saga1 1 Molecular Imaging Center, …
Manganese-Enhanced Magnetic Resonance Imaging: Overview and
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery of manganese conductance through calcium-permeable channels, MEMRI applications expanded to include functional imaging in the central nervous system …
Manganese-enhanced MRI of the myocardium
Manganese dipyridoxyl diphosphate (MnDPDP)-enhanced magnetic resonance imaging of acute reperfused myocardial injury in a model: part II: comparison with cine magnetic resonance imaging. Invest …
Manganese-enhanced magnetic resonance imaging (MEMRI)
This special issue of NMR in Biomedicine on manganese-enhanced MRI (MEMRI) is aimed at providing the readers of this journal with an extensive review of …
Manganese‐enhanced magnetic resonance imaging (MEMRI): methodological
Manganese-enhanced MRI (MEMRI) is being increasingly used for MRI in animals due to the unique T1 contrast that is sensitive to a number of biological processes. Three specific uses of MEMRI have bee...
Manganese-enhanced magnetic resonance imaging …
Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations Afonso C. Silva,1* Jung Hee Lee,1 Ichio Aoki2 and Alan P. Koretsky1 1Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, Bethesda, MD, USA
Identification of neural circuits controlling male sexual …
Using manganese-enhanced magnetic resonance imaging (MEMRI), we analyzed the activation of brain regions in the sexual incentive motivation (SIM) and the partner preference PP (tests) on weeks 1, 5, and 10 in male rats tested for 10 weeks. AIM.
Manganese-Enhanced Magnetic Resonance Imaging of …
Manganese-enhanced magnetic resonance imaging (MEMRI) has therefore been used as a surrogate marker for cellular calcium handling and interest in its potential clinical applications has recently re-emerged, especially in relation to assessing cellular viability and myocardial function.
Manganese-enhanced magnetic resonance imaging (MEMRI …
Nevertheless, current manganeseenhanced magnetic resonance imaging (MEMRI) tools have provided a viable method for visualizing cortical responses after evoked and/or spontaneous pain [2,3].
Automatic method for individual parcellation of manganese …
Aims: To construct an automatic method for individual parcellation of manganese-enhanced magnetic resonance imaging (MEMRI) of rat brain with high accuracy, which could preserve the inherent voxel intensity and Regions of interest (ROI) morphological characteristics simultaneously.
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI…
Manganese-enhanced magnetic resonance imaging (MEMRI) holds exceptional promise for preclinical studies of brain-wide physiology in awake-behaving animals. The objectives of this review are to ...
In vivo evaluation of cellular activity in αCaMKII …
In this study, we performed in vivo manganese-enhanced magnetic resonance imaging (MEMRI) to assess the regional cellular activity in the brains of αCaMKII HKO mice. The signal intensity of MEMRI 24 h after systemic MnCl 2 administration reflects functional increases of Mn 2+ influx into neurons and glia via …
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI)
MEMRI relies upon the following three main properties of Mn 2+: (1) it is a paramagnetic ion that shortens the spin lattice relaxation time constant ( T1) of tissues, where it …
Manganese-Enhanced Magnetic Resonance Imaging
Manganese-enhanced magnetic resonance imaging (MEMRI) relies on contrasts that are due to the shortening of the T 1 relaxation time of tissue water protons that become exposed to paramagnetic manganese ions. In experimental animals, the technique combines the high spatial resolution achievable by MRI with the biological …
Mapping accumulative whole-brain activities during …
In this study, manganese-enhanced magnetic resonance imaging (MEMRI) was used to map the accumulative whole-brain activities associated with a 7 …
Manganese-enhanced magnetic resonance imaging (MEMRI …
Manganese-enhanced MRI (MEMRI) is being increasingly used for MRI in animals due to the unique T1 contrast that is sensitive to a number of biological processes. Three …